Meantime he had written scripts for Frankie Howerd, Griff Rhys Jones, Mel Smith and others, and performed as a stand-up comedian. This led to presenting radio and television programmes, in particular Whose Line Is It Anyway? on BBC Radio 4 and then on Channel 4 TV, where it won a Bafta Award in 1989.
Also on Channel 4 he presented ten series of his chat show Clive Anderson Talks Back, picking up British Comedy Awards in 1991 & 1992, before moving on to BBC1 with Clive Anderson All Talk. He has interviewed many leading politicians, film stars, actors, comedians, musicians, singers and writers. In addition, Clive has presented a variety of other documentary, political, comedy, quiz, arts and live entertainment television programmes including The Big Read for the BBC and most recently The Guardian Sports Quiz for Channel 4. He chairs Unreliable Evidence, a legal discussion programme on Radio 4, and Chat Room, a satirical programme on Radio 2.